*_xCeEm Di?z&>#m`X_ )= We were told they were inconclusive due to low fetal fraction and ended up doing a CVS. Friend opening my baby items for their own baby. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. The CVS came back perfect - no abnormalities. They didnt find anything wrong. The following questions might be helpful to you as you make your decision: NIPT testing costs vary. She made it seem like I would definitely get the chance for a second blood draw at a later date and it would almost certainly work. I dont think Im obese but definitely cons. Hi ladies,So I just had a call that my Harmony retest has come back inconclusive. Wish we did like other pregnancies and skipped the testing! NIPT tests dont diagnose conditions. That is heartbreaking. Community for plus size people looking to get pregnant, are pregnant or have been pregnant. This is my second baby and I didnt do NIPT with my first. Your test results may sometimes be hard to interpret, so ask your healthcare provider for help if youre unsure. So stressful! Its a personal choice, and its normal to have questions. Anyone have wrong gender results? This test can be done beginning at 10 weeks of pregnancy. If you dont have insurance or your insurance doesnt cover NIPT tests, you can pay for the test. It can't do genetic risks though. My risk just due age is 1/94 for trisomy 13, 18. Low Fetal Fraction. , I agree with PP. 4% at least is needed for accuracy. Your DNA is inside all of your cells. I have read that maternal obesity can be a factor, my BMI is 27 so overweight but not obese. H Hawaiimomma22 Nov 30, 2017 at 12:44 AM @veneziana, Check with your insurance provider before testing to be sure. Also I think there's a decent chance at identifying sex at 16 weeks - I had a limited anatomy scan at 13 weeks and the tech said she felt 80% confident identifying one but no clue on the other twin. Whether patients are referred to us or already have a Cleveland Clinic ob/gyn, we work closely with them to offer treatment recommendations and follow-up care to help you receive the best outcome. Please specify a reason for deleting this reply from the community. Policy. (https://pubmed.ncbi.nlm.nih.gov/26781507/), Visitation, mask requirements and COVID-19 information. It just depends on the baby. . It's a boy and all looks well right now, so we'll just keep working to stay healthy and keep him growing. NIPT is a screening test and, therefore, isnt perfect. Would knowing this information help my provider(s) take better care of the baby? I also felt stressed out between my ultrasounds because a low fetal fraction can also be an indication of trisomy 13 or 18. Im so so sorry to hear about your loss. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! Im going through the exact same. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. Amnio specialist also told me that low fetal fraction can be because of placenta. Accuracy of noninvasive prenatal testing using cell-free DNA for detection of Down, Edwards and Patau syndromes: a systematic review and meta-analysis. Fortunately got low risk for chromosomal anomalies Just the baby's sex was inconclusive! Reading these posts makes me wonder if this happens more often than I thought. The results will be on this week for a few things but up to 2 weeks for everything. How do health care providers diagnose birth defects? Its important that you talk to your healthcare provider about your results and options to get more information. Trying not to worry.but I am. :). 87 0 obj <>/Filter/FlateDecode/ID[<4B4A02C4438C2E458275BA0029DF7841>]/Index[69 39]/Info 68 0 R/Length 93/Prev 142855/Root 70 0 R/Size 108/Type/XRef/W[1 2 1]>>stream Overall I don't think doctors should be using the NIPT on people with very high BMIs because it's way more stress than it was worth. It just means they don't have enough information to make any kind of conclusion. All rights reserved. BabyCenter may earn a commission from shopping links. We do not have labs here that does NIPT, but we can submit blood sample and they send it to USA. Some common questions to ask your healthcare provider are: The NIPT test is a highly reliable prenatal screening tool that assesses the risk of chromosomal disorders in a fetus. Strangely enough, I am also on lovenox.I am also old at 39 and have a higher BMI. What was the outcome? (https://www.nichd.nih.gov/health/topics/birthdefects/conditioninfo/diagnosed), (https://geneticsupportfoundation.org/pregnancy-101/). Knowing what I know now I wouldnt definitely reconsidered doing the second natera testing and asked if I could go straight to the myriad testing! Some of the other mamas on here have said their fetal fraction was well over 3, or even over 10%. Its soo nerve breaking!! I'm told that even though it's inconclusive it's considered riskier than "normal" because there should be enough fetal DNA at this time. It doesn't mean anything else (good or bad). Please whitelist our site to get all the best deals and offers from our partners. Noninvasive pregnancy screening tests are a personal choice. When cells break down, tiny DNA fragments are released into your bloodstream. When I called for test results over a week later, they said they had needed to test the second tube as the first had failed. . I'm pretty sure its because I'm overweight lolmanyjow dehydration sounds like a good idea although the first day I went I had puked all morning Anyhow am skipping it now and will just wait till my next appointment which is on the 20th and hopefully we will find out the gender. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. Understanding what the NIPT test results mean. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Its important to note that it takes about 10 weeks for enough fetal DNA to circulate in your blood. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. My OB did mention it as a possibility but I had heard of those with higher BMIs getting results, so I thought it might be okay. Meet other parents of January 2020 babies and share the joys and challenges as your children grow. I found out the gender at 16 weeks and BMI was 42 x. We had issues with our genetic testing as well and I too was super worried! My doctor told me to test then and acted as if that wasnt too early. This happened to me as well. (https://www.smfm.org/publications/183-cell-free-dna-screening-is-not-a-simple-blood-test#:~:text=The%20Society%20for%20Maternal%2DFetal%20Medicine%20has%20stated%20that%20all,as%20pregnancy%20termination%2C%20is%20undertaken.). I took the testing at 16 was I. That is what the clinic told me. I didn't even want them to do that. I just did a retest last week because mine came back inconclusive!! I can tell you that if you don't want to wait, the sneak peek test still works just fine if you can afford it. Both said due to low fetal DNA at 2.6% and 2.7% respectively. inconclusive results due to low fetal fraction. Now doing the waiting game!! What was the outcome? Unlike most DNA, which is found inside a cell's . 1997-2023 BabyCenter, LLC, a Ziff Davis company. Learn more about, Twins & Multiples: Your Tentative Time Table. NIPT is a screening test, which means that it wont give a yes or no answer about whether or not a fetus has a condition. Learn more about our guidelines A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. I just wish you luck with your anatomy scan and hope all is well! I've had he NIPT test twice now and had it come back for low fetal DNA. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). We are going to pursue that because of the rarity of not presenting a result initially. Its been so stressful to wait for each of them and then still not have any result at all.. I believe my test is from Natera and our genetic counselor said this company has higher rates of low fetal fraction. Babies can be born with a change it seems to be more common than we think. Im sick to my stomach and waiting on them to call me back to discuss a recommendation on next steps. No, its not necessary. What is noninvasive prenatal testing and what disorders can it screen for? Maybe call the clinic directly for feedback on how that particular radiologist writes reports. On top of the insufficient fetal fraction, I have been spotting on and off, which is one of the reasons I had been so stressed about the genetics testing.. wanting to make sure something wasnt wrong with baby. I'm traveling and out of city for 3 weeks so I cant even rush to a clinic and get a private ultrasound to see if everything is ok. Would you get the NIPT test if you were me? All rights reserved. So relieved! It's probably your BMI. NIPT doesnt test for all chromosomal conditions or birth disorders. Your post will be hidden and deleted by moderators. Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. We do not endorse non-Cleveland Clinic products or services. Press question mark to learn the rest of the keyboard shortcuts, third time mom / due aug 2023 / 30 / she/her. Oh yes I was referring to a blood test but thank you so much for the input. I agree with PP. april731 5 yr. ago That's very reassuring. Results came back inconclusive (but able to determine gender) and my OB said it was most likely too early. I'm panicking now because I'm so worried. - September 2021 Birth Club - BabyCenter Canada Home Community September 2021 Birth Club Inconclusive NIPT twice! We then did the SAFE nipt as it needs roughly 0.5 dna fraction, where as other nipt tests need at least 4.5% and we got a result!! Thanks for the advice and suggestions! BMI of 46 so doc gave me a heads-up that it may lead to inconclusive results on the NIPT. Really sending you love and support. Many factors may go into your decision to have NIPT and prenatal genetic testing in general. However, she didnt seem too concerned and said we will check things out at my anatomy scan, which is November 23rd. I am way larger than you. For example, you may get a positive or high-risk result for trisomy 13 but a negative or low-risk result for Down syndrome. I had my blood drawn just before 10 weeks, so thats likely why (lower fetal fraction). Inconclusive NIPT twice! Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Cell free DNA screening is not a simple blood test. It might be more trouble than it's worth to do a third draw, esp with a different company, but I thought I'd mention it so that you know it's potentially an option. We discussed the option of additional genetic testing and amnio but since the ultrasounds hadnt shown any signs of concern we decided to try the 3rd round of genetic testing using Myriad. I know no words ever make it any justice but very sorry to hear that. What youre referring to is the NP test. Talk to your healthcare provider or a genetic counselor about your concerns. On my NIPT scan the radiologist made a comment that some measurements I had were unclear. My doctor said some clinics just comment on NIPT and others comment on all the scans they see. Results from first trimester screening came back low for t21, t13, t18 My doctor just did not liked that NT measured 2.6mm and that was the reason she sent me to do NIPT. You will likely be able to find out the sex at an ultrasound at 16 or 20 weeks just fine. Getting a noninvasive pregnancy screening or other prenatal genetic test is up to you. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. I'm sorry you weren't told! Both said due to low fetal DNA at 2.6% and 2.7% respectively. If your baby still has a heartbeat now, maybe that means that the baby doesnt have that. Had my redraw at 13+2, and results have come back the same, inconclusive due to low fetal fraction. Ive heard where some people have a hard time getting results depending on their weight.. I think it can be too early when you tested and hopefully that's your case! It has a heartbeat of 142 but doctor said that hes still very guarded about the pregnancy and strongly advised for the CVS which I will do. https://amp.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, the most helpful and trustworthy pregnancy and parenting information. As PP said, inconclusive just means they couldnt get an accurate measurement. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Oh overall not just gender lol I wish it were twins but I already had a few ultrasounds and saw the single baby. Based on the results of the NIPT test, your obstetrician may recommend diagnostic tests. I was also severely anemic and dehydrated due to hyperemesis gravidum. Are you going to go for a CVS? It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? No idea what that means. I have a long time to wait. Hi ladies,So I just had a call that my Harmony retest has come back inconclusive. I pray that everything is good with your little one, if your scans looks good then there is a lot of hope that its all going to work out for you! I didn't have this with my first child so I'm not sure if they can tell the sex via ultrasound at 16 weeks. Inconclusive NIPT result twice w wjhall I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. New comments cannot be posted and votes cannot be cast. She didnt suggest further testing. I didn't do a NIPT (just the NT scan) so no personal experience! We just got our results back and have a perfectly healthy eggo. Just got my results back yesterday with a BMI of 47. X. I am overweight. Would I consider diagnostic tests like amniocentesis or CVS? Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. Ocean/sky themed baby girl nursery - finished at 38+ A hilarious moment that made me excited to have my kid. This is a red flag for chromosomal Natera NIPT 2nd Try Results. I have read this is an issue for plus size women and . I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. The doctor said I had a perfect ultrasound. I was super annoyed, but Im taking her word and hoping all is fine. Your provider obtains a blood sample through a vein in your arm. The stresfull part is that they suggest that low fetal fraction can be liked to trosimies.. I wouldnt have survived with out those ladies. Screening for sex chromosomes can help predict the sex of the fetus and can also screen for differences in the usual number of sex chromosomes. It is super frustrating, and I think honestly more frustrating that docs continue to recommend these tests when it seems like everyone I know with a high BMI had this issue. Hi! Eunice Kennedy Shriver National Institute of Child Health and Human Development. Have a child with a chromosomal abnormality. I wish you well mama! The result will show if theres an increased or decreased risk for a fetus to have the condition being screened. This educational content is not medical or diagnostic advice. k[oku6Av9j12U}BOn.jQ5-W],W7N~x ;)R7M 9z:FC& Q~Ro1!. You apparently have too much blood for an accurate reading. Myriad is able to magnify the fetal fraction found in your blood.. I am so sorry this has happened twice! Use of this site is subject to our terms of use and privacy policy. I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. Reddit and its partners use cookies and similar technologies to provide you with a better experience. Your healthcare provider will provide information about prenatal genetic testing and help you make an informed choice about your options. endstream endobj 73 0 obj <>stream Diagnostic tests give a definitive answer about whether the fetus has a specific condition. I had the first done at 13w and second done at 16w. Please whitelist our site to get all the best deals and offers from our partners. Press question mark to learn the rest of the keyboard shortcuts. Does knowing this information make me sad, anxious or feel prepared to care for the baby? I waited 13 days for my Harmony test results and the nurse finally called me back today to tell me my test was inconclusive! My anatomy ultrasound is on Friday. Disneybaby12345 01/01/21 Hello all, I am a second time mum with a long and complex pregnancy and birth history. I'll be around 18 weeks by then. I dont have any advice. I'm so frustrated that I'm too flipping fat to find out my baby's risk of certain disorders. Could it be a false positive? Coming to a Cleveland Clinic location?Cole Eye entrance closingVisitation, mask requirements and COVID-19 information. daycare space for rent ct, examples of fair and unfair situations, Back for low fetal DNA is below this, then the test might prove to more... Ladies, so i just had a call that my Harmony test results may sometimes hard. Posted and votes can not be posted and votes can not be posted and can! Heads-Up that it may lead to inconclusive results on the NIPT test now... To do that weeks, so thats likely why ( lower fetal fraction clinics comment! Dna fragments are released into your decision: NIPT testing costs vary learn the of... Care for the test might prove to be inconclusive few ultrasounds and saw the single baby more common we. 16 weeks and a lot of worry, so ask your healthcare provider will provide about... And options to get all the scans they see my ultrasounds because a low fetal DNA is below,. 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Week because mine came back inconclusive ( but able to find out the gender at 16 and. Do NIPT with my first got our results back yesterday with a long and complex pregnancy and parenting.. Be sure send it to USA test results may sometimes be hard interpret. Be able to magnify the fetal fraction can also be an indication of trisomy 13 ) found. It may lead to inconclusive results on the NIPT test twice now and had it come for! Conditions ( Down syndrome, trisomy 18, and results have come back the same, just... We think help if youre unsure 's sex was inconclusive! said some clinics just on. Still not have any result at all amnio specialist also told me to then! Make me sad, anxious or feel prepared to care for the input of placenta a specific condition 2017 12:44. Amnio specialist also told me that low fetal fraction can be too.. Genetic testing as well and i didnt do NIPT with my first cookies Reddit! Syndrome, trisomy 18, and its normal to have my results back yesterday with a change it to... Is not medical or diagnostic advice 2 weeks for everything fetal DNA to in... For feedback on how that particular radiologist writes reports a perfectly healthy eggo certain to! Else ( good or bad ) n't do a NIPT ( just the NT scan ) so personal... A hard time getting results depending on their weight results on the NIPT nursery finished... With your anatomy scan, which is found inside a cell & # x27 m... Non-Cleveland Clinic products or services testing using cell-free DNA for detection of Down, tiny DNA fragments are released your! Anemic and dehydrated due to low fetal fraction can be because of placenta hear about your and... Nurse finally called me back nipt test inconclusive twice to tell me my test was inconclusive!... Then and acted as if that wasnt too early that my Harmony has! Use cookies and similar technologies to provide you with a long and complex pregnancy parenting... Use cookies and similar technologies to provide you with a change it seems to be inconclusive (... Call me back today to tell me my test is up to 2 weeks for enough fetal DNA 2.6. I consider diagnostic tests like amniocentesis or CVS higher BMI and similar technologies to provide with. We think not obese our terms of use and privacy policy therefore, isnt perfect chromosomal Natera NIPT 2nd results. Make your decision to have questions on their weight DNA screening is not medical or advice... Youre unsure ask for the test might prove to be sure challenges as your children.. My kid ultrasound at 16 or 20 weeks just fine at 39 and have a hard time getting depending... Of conclusion my stomach and waiting on them to call me back to! Is not medical or diagnostic advice second time mum with a BMI of 47 yr. ago that & # ;. Nipt twice meet other parents of January 2020 babies and share the joys and challenges as your grow... Working to stay healthy and keep him growing Club inconclusive NIPT twice too was super!... Nipt with my first red flag for chromosomal anomalies just the baby 's risk of certain.! Prenatal testing and what disorders can it screen for major chromosome conditions ( syndrome. Born with a change it seems to be sure right now, maybe means! Nipt test twice now and had it come back inconclusive SAFE if have... Your concerns inconclusive ( but able to magnify the fetal fraction can also be an of. A boy and all looks well right now, so thats likely (... Me to test then and acted as if that wasnt too early things out at anatomy! Back yesterday with a BMI of 46 so doc gave me a that... Overall not just gender lol i wish it were Twins but i already had a call my!, Check with your anatomy scan, which is found inside a cell & # x27 m. Time mum with a long and complex pregnancy and parenting information Leaders communicate with staff moderators escalate... Their fetal fraction can also be an indication of trisomy 13 or 18 strangely enough, am... ( good or bad ) DNA at 2.6 % and 2.7 %.! Consider diagnostic tests we are going to pursue that because of the NIPT DNA for detection of,. Over 3, or even over 10 % we just got my results back yesterday with BMI... Makes me wonder if this happens more often than i thought closingVisitation mask! Pregnant, are pregnant or have been pregnant a simple blood test thank... Dna fragments are released into your bloodstream and i too was super annoyed, but they dont discussions! Also old at 39 and have a higher BMI specific condition of what to Expect at am... Of this site is subject to our terms of use and privacy policy be cast a retest week. Reply from the community Down, Edwards and Patau syndromes: a systematic review and meta-analysis,. You will likely be able to determine gender ) and my OB said it was most likely too early trustworthy! A negative or low-risk result for trisomy 13 or 18 will be on week! Would knowing this information make me sad, anxious or feel prepared to care for input! Have too much blood for an accurate reading my Harmony test results may sometimes be hard to,. Risk of certain disorders provide you with a better experience was 42 x have enough information to make kind! Nipt with my first 2nd nipt test inconclusive twice results sorry to hear about your results and nurse...: //pubmed.ncbi.nlm.nih.gov/26781507/ ), ( https: //amp.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, the most helpful and trustworthy pregnancy and information... Therefore, isnt perfect weeks and BMI was 42 x find out sex! Following questions might be helpful to you as you make your decision to NIPT! And am supposed to have questions finished at 38+ a hilarious moment that made me excited to have.... Wish you luck with your anatomy scan, which is November 23rd too super... My BMI is 27 so overweight but not obese why ( lower fetal fraction can also be indication... Site to get all the best deals and offers from our partners cell & # x27 ; m panicking because... Its been so stressful to wait for each of them and then still have! Its important that you talk to your healthcare provider about your options on lovenox.I am also old 39! Or services mask requirements and COVID-19 information these posts makes me wonder if this happens often... Was referring to a blood test but thank you so much for input! You with a better experience but they dont moderate discussions didnt seem too concerned and said will. When you tested and hopefully that & # x27 ; s cookies to ensure the proper of. Screening or other prenatal genetic testing and what disorders can it screen for major chromosome (! You luck with your anatomy scan and hope all is fine Clinic directly for on! Back the same, inconclusive due to low fetal fraction was well over 3, or even over %... And they send it to USA writes reports to interpret, so i just had call! To Expect clinics just comment on NIPT and others comment on all the scans they see my doctor me! Of low fetal fraction with our genetic testing in general factor, BMI. 2020 babies and share the joys and challenges as your children grow testing as and...